Prolonging Vitality for Optimal Executive Health: Insights from Dr. Sandra Kaufmann on Healthy Aging
Why we age and how to stop it is becoming much clearer.
The science of aging and longevity has always intrigued mankind. The quest for extending healthspan, not just lifespan, has driven various researchers and scientific advancements.
My guest, Dr. Sandra Kaufmann, Chief of Pediatric Anesthesia at the Joe DiMaggio Children’s Hospital along with being the author of two books: The Kaufmann Protocol: Why We Age and How to Stop It and The Kaufmann Protocol: Aging Solutions.
In this blog post, we'll discuss three major takeaways from the episode that demystify the process of aging and suggest practical ways to not only live longer, but live longer with more adventures.
For the full conversation, check out the episode below.
Watch the Full Episode Below
Dr. Sandra Kaufmann
Dr. Kaufmann began her academic career in the field of cellular biology, earning a Master’s Degree from the University of Connecticut in Tropical Ecology and Plant Physiology. Turning to medicine, she received her medical Degree at the University of Maryland and completed a residency and fellowship at Johns Hopkins in the field of pediatric anesthesiology.
Understanding Aging and Longevity
Dr. Kaufmann starts the conversation by stressing the importance of extending healthspan rather than lifespan. Healthspan, unlike lifespan, focuses on the quality of life, ensuring you can continue doing what you love for as long as possible. She explains the seven tenets of aging:
DNA alterations — Think of your DNA as an information hub. It’s packaged into chromosomes, which are protected by caps of non-coding DNA called telomeres. With each cell division, your telomeres shorten. This highly correlates with longevity. Along with telomere shortening, epigenetic modification (i.e. methylation) and the accumulation of DNA damage will fall under this tenet.
Mitochondria failure — Your mitochondria are essential to energy production in every single cell. They’re also highly susceptible to oxidative damage as we age. When your mitochondrial function starts to slide, cellular health and longevity are at risk.
Cellular (Aging) pathways — When it comes to aging pathways, there are three main pathways to keep in mind: 5’-AMP-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), and sirtuins. AMPK is an enzyme that regulates cellular energy metabolism. mTOR is an enzyme that regulates cell growth along with the recycling of organelles. Sirtuins are a family of proteins that regulate energy efficiency, programmed cell death (apoptosis), and other various cellular processes related to aging. Here’s the good news: these various metabolic pathways can be turned on or off to influence cellular aging depending on our daily behaviors and choices.
Quality control (aka DNA and protein-repair mechanisms) — Typically on average, each of our cells has at least 105 DNA errors per day at baseline (quite fascinating if you ask me). With that said, four key repair mechanisms will keep the damage in check. But as we chronologically age, these repair mechanisms become stressed (and less reliable). And when errors in your DNA and protein synthesis accumulate, your cells can fail to replicate usually.
Immune system response — Think of your immune system as your security system. With that said, there are three ways that it can also contribute to aging: an increased rate of inflammation as you chronologically age, a decreased ability to fight off infections, and a heightened risk of immune cells becoming potentially cancerous which could in a worst-case scenario lead to developing leukemia or lymphoma. Reminder: this is not medical advice ;)
Individual cell requirements — When it comes to our cells, they all move and operate under a different schedule. We have some cells that will last our entire lifetime while other cells are only good for a few days before needing reinforcements. As discussed, cells that are more on the longer side require much more support in terms of waste accumulation. Each of the different types of cells we have requires different protocols.
Waste management — Just as a household with a large number of humans will accumulate more weekly waste compared to a single household, our cells are the same way. The more our cells age, the more they accumulate waste. If the waste doesn’t get handed appropriately, that’s when potential issues can arise. One example is advanced glycation end products (AGEs) from the bonding of your glucose with lipids and proteins.
Dr. Kaufmann suggests that while the complexity of these tenets might seem intimidating, understanding them is the first step toward prolonging our vitality. This approach, referred to as the Kauffman Rating System, evaluates different molecular agents based on these seven tenets, creating a personalized guide for maintaining health and wellness as we age.
The Role of Key Aging Agents and Health Supplements
Next, Dr. Kaufmann dove into the significance of specific aging agents like Pterostilbene and Astaxanthin, and the role of sirtuin activation in aging. She suggests that individuals in their 40s should be particularly mindful of sirtuin failure. On a side note, as someone currently 37 as of this writing, I’ve already begun supplementing for sirtuins maintenance and optimization.
Moreover, she highlights the many benefits of Astaxanthin, especially for those who spend considerable time outdoors. Another cool thing about Astaxanthin is that the downsides are practically zero.
Health supplements, according to Dr. Kaufmann, play a significant role in longevity. She suggests using turmeric in its high bioavailability form and also discusses the benefits of carnosine, a transglycosylation agent. She also mentions berberine, a hypoglycemic agent that regulates glucose levels. Dr. Kaufmann insists that while supplements are beneficial, they should align with an individual lifestyle and specific requirements.
The Intersection of Personal Wellness, Pharmacology, and Healthy Aging
The conversation with Dr. Kaufmann emphasizes the critical role of personal wellness in healthy aging. It's not just about living longer, but about enhancing the quality of life.
Dr. Sandra Kaufmann suggests that while the aging process is inevitable, the way we age can be influenced by our lifestyle choices and specific wellness practices.
Lastly, in this episode, she discusses the importance of skin health and topical applications, indicating the significant role of personal care in healthy aging. Skin health can be thought of as both from a topical and oral standpoint. External and internal strategies.
To sum up, Dr. Sandra Kaufmann's insights underscore the importance of understanding the science of aging, the role of supplements, and the emphasis on personal wellness in prolonging vitality.
Aging is a complex process, but with a strategic approach, we can take control and enhance our healthspan, making the most of our life's journey.
This podcast episode serves as a valuable resource for anyone seeking to unravel the mysteries of aging and explore the science of healthy aging. With a better understanding of the mechanisms of aging, we can make informed decisions to live longer, healthier lives.
Connect with Dr. Sandra Kaufmann
Website — https://kaufmannprotocol.com/
(Book 1) The Kaufmann Protocol: Why We Age and How to Stop It — https://www.amazon.com/Kaufmann-Protocol-Why-Age-Stop-ebook/dp/B07BDKWVZH/
(Book 2) The Kaufmann Protocol: Aging Solutions — https://www.amazon.com/Kaufmann-Protocol-Aging-%20Solutions/dp/B0B5MVFBVQ/
Instagram — https://www.instagram.com/kaufmannantiaging/
Transcript
Julian Hayes II
(0:00) What does longevity and aging mean to you?
Dr. Sandra Kaufmann
(0:03) That's an excellent question. (0:05) What I think it means is just delaying morbidity and mortality. (0:10) Right now, if you ask any normal physician or normal person, you know that you start getting old, you start getting diseases of aging, and ultimately you are frail, and then you die.
(0:20) Of course, the alternative is falling off a cliff or getting hit by a bus, and none of those things sound all that great, right? (0:25) So the idea is to just to stave off or to decelerate the process of aging to give us the opportunity to do all of the things that we really like to do as long as possible. (0:36) So to me, it's really not necessarily about longevity.
(0:39) It's more about elongating your health span so you can go do those crazy whack-a-doodle things that you wanted to do as long as you possibly can do them.
Julian Hayes II
(0:52) Welcome, everyone, to another episode of Executive Health and Life. (0:55) I'm your host, Julian Hayes II, and as I always like to say, back with another fascinating guest talking about some interesting things. (1:01) So my guest today opens up her second book with a quote from Stephen Hawking, which I love, which states that, I'm not afraid of death, but I'm in no hurry to die.
(1:10) I have so much I want to do at first. (1:11) This is a great way to think about aging and longevity. (1:14) A lot of times, people think about you just want to live a long time just to live a long time or that you're afraid of dying or whatnot, but to me, it's all about adventures and experiences and being the best that you can be as long as you can be.
(1:25) So a little background on my guest is that she's the chief of pediatric anesthesia at the Joe DiMaggio Children's Hospital. (1:32) She's an athlete. (1:33) She runs.
(1:34) She swims. (1:35) She rock climbs around this busy hospital schedule, and if that's not enough, determined to enjoy her physical activity and to keep being in her 30s and an athlete, she decided to carry out another hobby, which is to really learn about aging and really do an extensive review of the scientific literature to better understand our bodies and to help all of us better understand our bodies. (1:55) So this has led to her publishing two books, which are quite thorough but very informative.
(1:59) Lastly, she applied to a NASA mission. (2:01) Unfortunately, she was not accepted, but nevertheless, I appreciate the effort. (2:05) I am speaking with none other than Dr. Sandra Kaufmann. (2:07) How are you doing today, Sandra?
Dr. Sandra Kaufmann
(2:10) I am doing great, and I'm looking forward to our conversation.
Julian Hayes II
(2:13) Well, I appreciate that. (2:14) One thing that I have to know is what inspired you to pick the specialty that you chose.
Dr. Sandra Kaufmann
(2:22) Actually, it's sort of by default. (2:25) I'm an anesthesiologist because it sounds really silly. (2:28) I wanted to be a neurosurgeon.
(2:30) My dad said, that's crazy. (2:32) Neurosurgeons are nuts. (2:34) You should be a general surgeon.
(2:35) So I spent a year doing general surgery, and I thought it was very inelegant. (2:39) So then I applied to be a neurosurgeon, and I did that for a year, and I decided that the outcomes were absolutely terrible. (2:46) I mean, it's really fun to go poking around in people's brains, taking out a tumor or two, you know, whatever.
(2:53) But then I thought, what can I actually do to make a difference? (2:55) And I ended up being an anesthesiologist because I like the way drugs affect the body. (3:00) I like the way the body sort of metabolizes drugs, and that sort of led me down the wormhole to understanding longevity because a lot of longevity is pharmacology and pharmacobiology.
(3:11) So that's sort of how I got to where I am.
Julian Hayes II
(3:13) You know, speaking of pharmacology, I wish we had your explanations, the way you explained it in your book compared to the pharmacology I was taught in school. (3:22) My pharmacology was not that good for me, but I like the way you explained it. (3:26) It was a lot, for some reason, the detail that you explained it, maybe it was because it was more in a story format that I tend to grasp it a little more.
(3:34) So in case you need another hobby, I think you could probably teach that as well.
Dr. Sandra Kaufmann
(3:40) Oh, good. (3:40) Yeah, I'll put that on my list. (3:42) Yes, yes, absolutely.
(3:44) No, but I think you're absolutely right. (3:46) We understand things by stories, and if you can create a story out of something that's understandable and it's memorable, then you'll never forget it. (3:53) So I do like to treat molecules like people and give them relationships and personalities because I find it vastly entertaining to do it.
(4:01) And I'm curious, what does— My professors wouldn't agree with that, but it is what it is.
Julian Hayes II
(4:05) Probably not. (4:07) What does longevity and aging mean to you?
Dr. Sandra Kaufmann
(4:11) That's an excellent question. (4:13) What I think it means is just delaying morbidity and mortality. (4:17) Right now, if you ask any normal physician or normal person, you know, that you start getting old, you start getting diseases of aging, and ultimately you are frail, and then you die.
(4:27) Of course, the alternative is falling off a cliff or getting hit by a bus, and none of those things sound all that great, right? (4:32) So the idea is to just to stave off or to decelerate the process of aging to give us the opportunity to do all of the things that we really like to do as long as possible. (4:43) So to me, it's really not necessarily about longevity.
(4:47) It's more about elongating your health span so you can go do those crazy wackadoodle things that you wanted to do as long as you possibly can do them. (4:56) So that's what it is for me.
Julian Hayes II
(4:59) I like that. (5:00) I think a lot of times we overcomplicate when you hear the word longevity or aging or all that stuff. (5:05) But it really just boils down to I want to keep enjoying life even as I take more trips around the sun.
Dr. Sandra Kaufmann
(5:11) That is exactly right. (5:12) And it's really funny because people think, oh, well, this is crazy stuff that you're doing. (5:16) It's wackadoodle.
(5:17) I'm just going to stick with the normal stuff. (5:18) But we know what happens to the normal stuff, right? (5:21) There's death tables at insurance places.
(5:23) We know that by the age of 60, 65, 70, you're going to get cancer. (5:27) You're going to get cardiovascular disease. (5:29) You're going to not sleep well.
(5:30) You're going to need glasses. (5:32) All of these things have been tried out for millennia, for a zillion, zillion years. (5:38) So the alternative is just to try to make it better.
(5:41) And we can make it better. (5:42) We don't have all the answers yet, but we can certainly be way better off than we would be if we weren't into longevity.
Julian Hayes II
(5:48) Absolutely. (5:49) And I think a great place to start with that is for the reason, why do we age? (5:53) That's a huge question.
(5:55) And depending on who you talk to, you'll probably get a bunch of different answers. (5:58) But I like the way that you broke that down is that we have some core tenets of aging.
Dr. Sandra Kaufmann
(6:03) Right. (6:03) So I started life as a cell biologist before I went to med school. (6:08) And so I just I'm obsessed with the cell.
(6:10) And people sometimes think about aging in terms of systems, right, your immune system versus your heart versus your lungs. (6:15) But I am cell based. (6:17) So everything that I've talked about is sort of comes from the cell.
(6:20) And after analyzing a zillion articles and bench research, I decided that you could sort of arrange all of the reasons that your cells age into seven big piles. (6:31) And I created what I call the seven tenants of aging. (6:34) And this is where it's going to get really sort of scientifically boring and people be like, oh, my God, here we go.
(6:39) But I'm happy to run through them. (6:41) All right. (6:42) So tenet one is called DNA alterations.
(6:46) And these are the things that go wrong in your DNA, specifically in every cell, because almost all cells have DNA. (6:52) This is telomere shortening. (6:54) Most people have heard about that.
(6:55) Of course, every time a cell replicates, it gets shorter, also gets shorter under oxidative stress and glycation and that sort of thing. (7:01) But that's a big problem. (7:02) Secondly, in this category is epigenetic modification.
(7:06) You have I call them decorations, but really they're methyl groups, phosphate groups, acetyl groups that sit on top of your DNA or your histones, which is what your DNA is wrapped around. (7:16) And these change over the course of time and they sort of determine how well or how not well you age. (7:22) And epigenetic modification is why identical twins look less and less alike as you get older.
(7:27) So it's all it's not your genetics per se, it's your epigenetics. (7:30) So that's important. (7:31) And then the last thing in the DNA category is structural integrity of your DNA.
(7:35) As you get older, it just changes. (7:39) But the good news is we know how it changes. (7:41) And so we can reverse some of those changes.
(7:44) So that is tenet one. (7:47) So everyone's going, oh, my God, there's six more of these. (7:51) So tenet two has to do with your mitochondria.
(7:55) The mitochondria, if you guys remember from the fifth grade, it's a little organelle that makes energy. (8:01) Mitochondria fail for very specific reasons. (8:03) The easiest thing to look at is you make energy in mitochondria via the electron transport chain and you need some baseline ingredients to do that with, one of which is NAD.
(8:16) And most people by the time they are 40 are NAD deficient, so you don't make energy as much. (8:21) You have three sirtuins and we'll get to sirtuins in a little bit, but three, four and five drive the mitochondria. (8:28) Sirtuin three is uber important.
(8:29) It starts dropping by the time you're 35 to 40. (8:32) If you don't activate your sirtuin three, your mitochondria fail. (8:35) So that's another mitochondrial failure problem.
(8:38) Also in your mitochondria, you develop what we call free radicals because oxygen gets radicalized because of the electron distribution of the molecule. (8:48) So every time you create energy, you create free radicals. (8:51) Free radicals destroy your lipids, your DNA, your protein.
(8:54) So the more energy you use, the more damage you are sort of creating within your mitochondria. (8:58) So that's a problem. (9:00) Also in your mitochondria, there's fission and fusion problems, mitochondrial biogenesis problems.
(9:05) All in all, soup to nuts, there's probably like six different categories of reasons that your mitochondria bite the dust. (9:10) That is tenet two. (9:12) You're like, okay.
(9:14) Tenet three I call pathways. (9:17) There are probably hundreds of aging pathways. (9:20) The sirtuins are the big ones.
(9:21) You have seven mammalian sirtuins. (9:23) One, six and seven sit in your nucleus. (9:25) Three, four and five sit in your mitochondria.
(9:27) Two sort of flits around your cell. (9:29) And these pathways histone deacetylases control all cellular homeostasis. (9:34) They control if you're making free radical scavengers.
(9:37) They control what genes get translated and transcribed. (9:42) They control your circadian rhythms. (9:44) They control where your fat gets distributed as you get older.
(9:47) So as you do get older, in your 30s to 40s, your sirtuin levels fall and everything goes kind of a wackadoodle and you lose cellular homeostasis. (9:56) It's a huge one. (9:57) Also in pathways, we talk about AMP kinase.
(10:00) This is an enzyme that monitors how much energy you have. (10:03) And it's one of the reasons that caloric restriction diets actually are very good for longevity. (10:07) As well, there's the mTOR pathway in this category.
(10:11) And this sort of controls, it monitors how much energy you have and how much nutrient you have and then it builds things. (10:17) So this is sort of like the pathway of youth that should get turned off as you get older and it doesn't. (10:21) And it forces your cells to do things that it probably can't do and end up with a variety of pathologies.
(10:27) That is three. (10:29) Four is what I call quality control. (10:32) This is because you have significant damage to your DNA and to your proteins as you get older.
(10:38) So you have very specific quality control mechanisms in place. (10:42) You have four DNA repair mechanisms and you have a whole system of proteostasis measures to keep your proteins intact. (10:49) I also put autophagy in this category because that's sort of cellular recycling.
(10:53) When the quality drops, you recycle your organelles. (10:56) So that's quality control. (10:58) Let's see.
(10:58) Five is your security system. (11:01) This is your immune system that keeps you safe as you are younger. (11:03) It turns on you as you get older.
(11:05) So you become more inflamed over the course of time. (11:08) Category six is more of a grab bag. (11:10) This is called individual cell requirements.
(11:13) This is the idea that a stem cell and its niche, we need to sort of nourish and take care of versus a senescent cell or things we need to get rid of. (11:21) And it's also the understanding that a red cell has different requirements than a liver cell versus a brain cell. (11:27) And then lastly, ten at seven, I call waste management.
(11:30) This is mostly glycation issues. (11:33) It's also some like lipofacial accumulations. (11:35) But glycation is a huge reason that we age.
(11:40) You glycate or sugar sort of sticks to a whole lot of things, create these structures called AGEs, which are advanced glycation end products. (11:47) These coat a lot of your tissues, destroy them as well as causing huge inflammatory issues. (11:53) Anyway, so soup to nuts, those are the seven tenets of aging.
(11:57) I'm sure over the course of time we will find out or determine that there are more cellular failures. (12:01) But I will fit those into the seven tenets wherever they most likely fit.
Julian Hayes II
(12:08) So when you explain that to someone and we go over these seven things, the first step probably somebody's like, wow, this is a lot. (12:14) This seems very complicated. (12:16) And so at step one for someone who maybe comes across this and they have these things and they want to start to get more into aging and longevity, what's kind of the first approach that you recommend for them?
(12:30) Is it to kind of find out some areas that they're weaker in than others or something?
Dr. Sandra Kaufmann
(12:34) So that's an excellent question. (12:36) I sort of blow through these things and people go, uh-huh, uh-huh. (12:39) And they get like that, like, you know, sort of shady look in their eyes, like they have no idea what I'm talking about.
(12:43) They're like, okay, what do I do? (12:45) Right. (12:45) That's what people really want to know.
(12:46) What do I want? (12:47) What do we do? (12:48) And so what I did is I created something called the Kaufmann rating system, and I took the standard and then as the years progressed, the not so standard molecular agents and rated them in each of the seven tenets of aging. (13:01) So now I think I'm up to 50 some different agents and they come with a seven digit rating number, sort of like a little barcode. (13:08) And so when people want to figure out what they should take, it's all a mathematical algorithm. (13:14) So people don't actually have to understand all of the categories.
(13:17) All I have to do is understand that numbers are good. (13:20) So I had these on my website. (13:23) They're huge, giant charts of numbers and suggestions and algorithms and all that sort of thing.
(13:28) Inevitably, people always just want to be spoon fed stuff. (13:31) So what always happened is I'd give them, you know, a ton of information. (13:35) Then they would say, yeah, now what do I do?
(13:37) So I created something called the panacea. (13:40) And the only reason it's called the panacea is the letters consistently like sort of starts to spell the panacea and then falls off. (13:48) So not all of the letters are there.
(13:50) But the idea is that I took the top five or six agents that would cover all of the tenets of aging and made it easy for people. (13:56) So the P in panacea stands for Pterostilbene and is interchangeable with resveratrol. (14:03) And they are still beans and they do many things in many categories.
(14:07) But the most important thing is that they are very, very potent sirtuin activators. (14:12) And as I said before, if you don't address the sirtuin failure by the time you're in your 40s, all of your cellular homeostasis sort of goes by the wayside. (14:20) So sirtuin activation is incredibly important.
(14:23) So that gets a P. (14:25) Panacea, PA. (14:27) A is astaxanthin.
(14:29) You need free radical scavenging. (14:31) As you get older, your endogenous free radical scavenging abilities don't do as well. (14:36) So people, you can either boost them by boosting your NRF2 factors or you can just take regular free radical scavengers.
(14:43) And this is one of those. (14:44) Astaxanthin is amazing. (14:45) Comes from algae.
(14:47) There's no problems with taking it. (14:51) And anyone can take astaxanthin for the most part.
Julian Hayes II
(14:55) Let's speak into that one, which I take that as a favorite of mine. (14:59) There's two different. (15:01) Yeah, I love it.
(15:02) I actually think I heard it from you a long time ago. (15:05) You're the one who started me on that. (15:07) And the only thing I had to decide was the dosage to take.
(15:10) I took the 12. (15:12) And so anytime someone's very active, would you recommend them to take the 12?
Dr. Sandra Kaufmann
(15:17) Oh yeah. (15:18) Yeah, yeah, yeah, yeah. (15:19) So a standard low dose is four.
(15:21) I think it comes in fours, eights, tens, twelves. (15:23) And now there's a liposomal 24 milligram that I'm trialing. (15:27) But the more active you are and the more outside you are, the higher milligram is you need without a doubt.
Julian Hayes II
(15:34) Okay. (15:35) Yeah. (15:36) So I actually might go over 12 then now that I think about it then.
(15:39) Yeah.
Dr. Sandra Kaufmann
(15:41) There's really no downside. (15:46) Very, very, very, very rare downsides to astaxanthin.
Julian Hayes II
(15:50) Yeah. (15:50) And I think it's a good epigenetic modifier of some genes. (15:54) I can't remember off the top of my head right now as well.
(15:55) I think one of them is the FOXO gene.
Dr. Sandra Kaufmann
(15:57) That could be, could be.
Julian Hayes II
(15:59) Yeah.
Dr. Sandra Kaufmann
(16:00) But it's a free radical scavenger. (16:02) It activates your endogenous things. (16:03) It's an anti-inflammatory.
(16:05) It is just a miraculous molecule that nature has given us.
Julian Hayes II
(16:11) And going back to the first one, pterostilbene, with the sirtuins, is there any signs that say you said around 40? (16:21) So would there be any signs that maybe it's even earlier for some people?
Dr. Sandra Kaufmann
(16:25) Absolutely. (16:26) Absolutely. (16:27) So big things that people generally notice are lack of sleep.
(16:33) Sirtuins drive circadian rhythms. (16:35) So people that used to sleep six hours or eight hours, now we're down to six hours. (16:40) You know, the reason that old people have the early birth specials and then they only sleep five hours or three in the morning, that's a sirtuin deficiency.
Julian Hayes II
(16:49) Oh, okay.
Dr. Sandra Kaufmann
(16:50) When people say, I eat exactly the same thing, I exercise exactly the same, but I'm starting to get belly fat, that's a sirtuin deficiency.
Julian Hayes II
(17:00) A lot of times people will probably go to what, something with belly fat, I'll think of something with metabolic related, right?
Dr. Sandra Kaufmann
(17:06) Yeah. (17:07) But sirtuins determine all cellular homeostasis. (17:10) And what's really interesting is sirtuin-3 that lives in the mitochondria determines the fuel source for your mitochondria.
(17:16) And it can shift between glucose, fatty acids, and ketones. (17:20) So depending on the activity of your sirtuin-3, you can sort of play with what you are going to burn. (17:26) And as you get older, you'll lose, use less fatty acids and therefore you end up with hyperlipidemia.
(17:32) So by sort of mucking around with these sirtuin-3s, you can change a lot of aspects of your metabolism.
Julian Hayes II
(17:41) So general sirtuin activator right there, right? (17:45) So that's going to hit the 1, the 3, and the 5, and the 6?
Dr. Sandra Kaufmann
(17:50) So the answer is pterostilbene and resveratrol extremely good at 1, and kind of okay at the others. (17:58) And in fact, it's really sort of interesting, sirtuin-1 actually deacetylates sirtuin-3 and sort of turns it on. (18:05) But over the age of 50, where I'm sitting, it's just easier to take, I take a sirtuin-1 and a sirtuin-3 activator.
(18:12) So sirtuin-3 activators are actually, my favorite are dihydromyricetin or honokiol, just because I think you need the extra boost as you get older. (18:22) When you are younger in your 40s, then probably sirtuin-1 activator is just fine. (18:26) And all of this also depends on how many things you're willing to swallow a day and how avidly you want to sort of go down the longevity rabbit hole.
Julian Hayes II
(18:34) Yeah, because I saw, I think I saw now, I think I saw a sirtuin-6 supplement, I think.
Dr. Sandra Kaufmann
(18:40) Yeah, so cyanidin is sirtuin-6. (18:43) It lives in the chromatin of your nucleus, and it's sort of like an accessory to 1. (18:49) So absolutely, you know, the older you get, the more specific you have to be in your activators.
Julian Hayes II
(18:56) Right. (18:57) So that's a very good way to put it. (18:59) It's a very good way to put it.
(19:01) So I guess let's go back to the panacea. (19:03) So we are at letter N.
Dr. Sandra Kaufmann
(19:04) So N, so actually, this is really important. (19:06) So everyone over the age of 40 needs an NAD precursor. (19:11) We become NAD deficient.
(19:15) And you need NAD for very specific things in your body. (19:18) So number one, you need it for the electron transport chain. (19:21) Without NAD, you're just not going to make the energy that you did at one point.
(19:27) Two, it is a necessary cofactor for your sirtuin activation. (19:31) So just like we just talked about, you can activate your sirtuins as much as you possibly want. (19:36) And if you're NAD deficient, nothing's going to happen.
(19:39) Three, you use it to repair your DNA. (19:43) Everybody every day has 10 to the fourth or 10 to the fifth DNA errors per cell per day. (19:49) If you do not fix them, you're going to either become senescent, or you're going to get cancer.
(19:53) So third reason NAD is important. (19:55) And the fourth reason is that it's a communication device between your nucleus and your mitochondria. (19:59) It sort of tells your body what you're yourself what you're going to do.
(20:04) So as you get older, and you're NAD deficient, a lot of things don't work very well. (20:08) So it's absolutely pertinent. (20:11) The question then is, what precursor do you take?
(20:15) At the moment, in terms of oral supplementation, your choices are nicotinamide riboside, or nicotinamide mononucleotide. (20:22) There's sort of a raging war about that at the moment. (20:24) And then there's also IV versions, there's patches, there's nasal sprays, there's all sorts of ways.
(20:30) There's an escalating war for people to buy their different brands, because everyone knows it's, you really need to have something going into you.
Julian Hayes II
(20:38) Yeah, it's a, it's one of the hottest things on the market right now in terms of it's so many different things coming up. (20:43) And it's interesting. (20:45) I mean, for the great, I think it's good.
(20:47) But then also, it's probably confusing for the to the general person who's hears about it. (20:52) And then they're like, I don't know which one to do. (20:54) And I think they're pretty close.
(20:56) I, I tend, I guess, to use NMN, NMN.
Dr. Sandra Kaufmann
(21:00) I will tell you that you're 36.
Julian Hayes II
(21:02) Oh, I just turned 37.
Dr. Sandra Kaufmann
(21:04) Oh. (21:07) You probably are not all of that terribly deficient. (21:10) So don't go nuts.
Julian Hayes II
(21:11) No, I didn't go nuts. (21:12) It's very low.
Dr. Sandra Kaufmann
(21:13) Okay. (21:14) Obviously, life is a bell shaped curve. (21:16) So generally speaking, by the time you hit 40, you're going to be start becoming deficient.
(21:22) At 37, you're like, yeah, maybe a little bit, don't kill yourself, don't spend a ton of money until you actually sort of have to.
Julian Hayes II
(21:29) Yeah, that's, that's kind of what I do. (21:30) You know, you know, when I hear about this, you know, I looked into things like Astaxanthin, right? (21:35) That's something that's everyone, no matter the age is beneficial.
(21:38) And then like you said, as you get older, that's when you start adding those things. (21:41) So and I think that's a great way, you know, as we're going through this now is that how people can kind of put together if that you come across so many different supplements, so many different compounds that you can use so many different, like, if you think about, how can I improve my cardiovascular system, there's probably 20 things that we can easily name off the top of our head. (22:00) So how do you choose which one?
(22:01) And so that's where you think of the bio individuality, you think about your age, your lifestyle circumstances, etc, etc.
Dr. Sandra Kaufmann
(22:07) Absolutely. (22:08) Yep. (22:08) Lots of variables.
Julian Hayes II
(22:10) So the next one is, let's see, P A N and C A. (22:14) Is that it? (22:15) Right?
Dr. Sandra Kaufmann
(22:15) Yeah. (22:15) So actually, this is where it gets screwed up. (22:17) So now we've got two C's.
Julian Hayes II
(22:19) Okay.
Dr. Sandra Kaufmann
(22:20) So the first one is curcumin. (22:24) And this is a bit misleading, because everyone's like, Oh, I eat turmeric, I'll be fine. (22:29) Turmeric only has one to 3%, or even up to 5% sometimes curcumin, but the bio availability of straight curcumin is really terrible.
(22:38) So in order to truly take advantage of this molecule, you have to find something that's bioavailable. (22:44) And the good news, and the reason that we're doing this is because it's one of the strongest anti-inflammatories that we have. (22:50) It is just an absolutely remarkable molecule.
(22:53) And again, you know, capitalism is doing us favors. (22:56) There has been an escalating market of increasing bioavailable substances for like the last decade. (23:03) So now you get it in a nanomycele or a liposomal formulation.
(23:07) There are just so many out there. (23:09) But people that say, Oh, I just take turmeric. (23:11) Yeah, that's just, that's old fashioned and not going to cut it.
Julian Hayes II
(23:14) How big of a difference is 2 forms? (23:16) And I, because I know off the top of my memory, I don't remember which one I have. (23:20) And it's a percentage, right?
(23:22) Some of those has like a percentage breakdown.
Dr. Sandra Kaufmann
(23:25) So different people, depending on the company, they advertise it differently. (23:30) Right. (23:31) I happen to use one that's in a nanomicelle. (23:34) And there's the big advertising campaign is that it's 277 times the bioavailability of standard stuff, right? (23:42) The liposomal stuff is probably maybe a hundred times more bioavailable. (23:49) The rest of it kind of hard to say, you know, the old fashioned way is adding pepper to it because pepper decreases liver enzymes so that it sort of lasts in your body a little bit longer.
(23:59) Um, but generally speaking, most of them are labeled a high bioavailability and that's what you're looking for in the label.
Julian Hayes II
(24:06) Okay. (24:09) So that sees it out of the way.
Dr. Sandra Kaufmann
(24:11) So the next letter I can see is carnosine.
Julian Hayes II
(24:14) Okay.
Dr. Sandra Kaufmann
(24:16) carnosine is, it's a dipeptide. (24:18) It's naturally occurring in our bodies. (24:20) And the reason that it is part of the panacea, because it's one of the strongest trans glycosylating agents that we have.
(24:27) And what that means is when glucose decides to stick to a protein and form an AGE, the first half of the process is reversible. (24:37) The second half of the process is not reversible. (24:39) So if you introduce an agent that's more attractive to a glucose molecule, the glucose will jump off whatever it was going to destroy, hit the karnosine, and then you will excrete it out and you lose some glucose.
(24:52) So trans glycosylation is absolutely pertinent. (24:56) Um, one of the practical ways that we know this works is as you get older, uh, people tend to need reading glasses, right? (25:03) It's presbyopia.
(25:04) People can't, um, move their lenses because they get glycosylated and they get, you know, it's oxidative stress and the like. (25:11) So you can actually get carnosine eye drops as you get older. (25:15) Um, and it prevents or even reverse some aspects of presbyopia because it's a trans glycosylating agents.
(25:21) It's kind of cool.
Julian Hayes II
(25:22) So, and I hear about this. (25:24) What about, is this comparable to berberine?
Dr. Sandra Kaufmann
(25:27) Would you know? (25:29) Okay. (25:29) So, so berberine is a hypoglycemic agents, right?
(25:33) It's actually extremely similar to metformin. (25:36) Um, and what people tend to do now, studies have shown that, um, you split your, your dose of metformin. (25:43) So you take 500 metformin, 500 of berberine, uh, it's an AMP kinase activator.
(25:48) It lowers your blood glucose. (25:49) It changes your gut microbiota. (25:51) It does a variety of things.
(25:52) It is not however, a trans glycosylating agents.
Julian Hayes II
(25:56) Okay. (25:56) So someone who's really, if that's a focal area, like the metabolic component, combining those two things would be an ideal solution.
Dr. Sandra Kaufmann
(26:05) Oh, absolutely. (26:06) So what I've also done is if you look at the seven tenants, uh, you can identify what diseases correlate to which tenants. (26:14) Uh, so for example, if you are thinking about if you are a diabetic or pre-diabetic, or you're worried about it, let's say you had gestational diabetes or something, you want to focus all of your strengths on tenants seven.
(26:25) And there are probably seven, eight, nine really good ways of overcoming glucose. (26:32) Um, you know, some people just don't eat it. (26:34) Like, you know, kudos to them.
(26:35) I, and I, I am a self-confessed junk food junkie. (26:39) I eat a lot of glucose, but I also take 17 different things to block or get rid of extra glucose in my body. (26:46) So there's many ways it's going to get, um, but you're absolutely right.
(26:49) If these are issues that you have, you focus on that particular tenant to sort of maximize strategies.
Julian Hayes II
(26:56) I like that philosophy instead of a lot of times people say, just, you know, fight your weaknesses or whatever, and you just don't worry about that. (27:03) You take, you take your strengths and it becomes, it becomes a mute point.
Dr. Sandra Kaufmann
(27:08) Yeah. (27:09) Part of, you know, every, everyone has a different philosophy and clearly people are going to agree with me or disagree with me. (27:15) You can either make your life blooming, miserable, and give up everything that you think is fun for longevity, or you can just go, eh, this is what I'm going to do.
(27:23) How do I overcome it? (27:25) Um, many, many ways it's going to get. (27:27) So for example, I always have wars with people that like to do like the cold plunge.
(27:31) Right. (27:32) And I understand that it's good for you. (27:34) It activates a variety of like shock proteins and you know, it does a lot of good things.
(27:39) It just looks blooming miserable. (27:41) I would never jump into an ice bath. (27:43) That just sounds terrible, right?
(27:45) There are other ways to do exactly the same damn thing. (27:49) So pick your poison. (27:51) You don't have to do everything that's perfect.
Julian Hayes II
(27:53) Yeah, absolutely. (27:54) I agree with that. (27:56) It's um, and I think that's sometimes that's the barrier that people think I know with my family, cause I'm one of them.
(28:01) I live quite differently than a lot of my family. (28:04) And so at times at the beginning it looked intimidating cause they're like, I don't want to do all this exercising. (28:10) I don't want to eat the same or a lot of the same things that you eat and take the, take the compounds and supplements that you take.
(28:16) I was like, you don't have to do that. (28:17) Uh, it's very different, but I liked that philosophy also. (28:20) Cause I think about that with exercise.
(28:21) So like maybe I have to overcome a few more free radicals and a little more inflammation and pay a little more attention to that if I'm going to be training excessively, but I enjoy it. (28:30) And it's easier to stick with the process then, then just, you know, trying to avoid every little thing, you know, part of, part of this whole thing is to become more resilient.
Dr. Sandra Kaufmann
(28:42) Yeah. (28:43) It's basically to make your life what you want it to be. (28:46) Right.
(28:46) Like I'm an exercise junkie too. (28:48) You know, I absolutely love it. (28:51) And I know that I'm going to cause massive inflammatory aspects of my body.
(28:56) That's okay. (28:57) Right. (28:57) I'm on 17 anti-inflammatories.
(28:59) It's totally okay. (29:00) Right. (29:00) You let the damage hit, you hypertrophy your muscles, you feed them, you know, there's the big war of, do you take your branch chain amino acids or you do take rapamycin?
(29:08) Like what do you want to do with like your mTOR pathways? (29:10) Well, there's a lot of these kinds of crazy choices that you make to fit your lifestyle.
Julian Hayes II
(29:15) Yeah. (29:15) You know, I hear mTOR and rapamycin, that's a, isn't that a, um, that's an immune system depleter, right? (29:21) Doesn't it?
Dr. Sandra Kaufmann
(29:23) So the answer is yes. (29:24) So rapamycin absolutely is an immunosuppressant, uh, in the real world, in the world of Doctor ville, we give it to people for kidney transplants. (29:32) They put it in stents so that you don't become fibrotic.
(29:36) Um, yeah, it is a big, powerful drug. (29:38) However, people are using it, um, off label as an mTOR inhibitor to try to, you know, by turning mTOR off a lot of laboratory animals do significantly better. (29:49) It, um, it, it definitely can help, but I, uh, I have serious concerns about it.
(29:56) So I'm sort of an anti-rapamycin person until they come up with more specific rapalogs. (30:01) I think it's sort of a bad idea at this moment, but who's to say, yeah, that's pretty much.
Julian Hayes II
(30:07) Yeah. (30:08) I had a few people ask me opinions on it. (30:09) I'd said for me, I don't, I mean, even if I was in that reach, I was, I'll pass on it.
(30:15) I'm sure it's benefiting something, but for, I don't know. (30:18) So I just have a question mark right now. (30:21) We'll see.
Dr. Sandra Kaufmann
(30:22) Yeah. (30:22) I think that by the time, well, it'd be a while for you. (30:26) I think in the seventies, eighties, um, small doses are going to prove to be beneficial.
(30:32) Um, on the other hand, uh, I definitely am waiting for the rapalogs that there's a difference between torch one and torch two. (30:37) And I think we need to be more specific about what we are inhibiting, but you know, the future is coming. (30:42) So we'll see what happens.
Julian Hayes II
(30:44) Exactly. (30:45) So, okay. (30:45) Is that it's a panda.
(30:47) See? (30:47) Yeah. (30:47) Is there a, at the end, right?
(30:48) At my spelling?
Dr. Sandra Kaufmann
(30:49) So people go really five, only five. (30:51) Then I throw an EGCG, um, which is the green tea because it is an extremely powerful epigenetic modifier. (30:59) Um, people love green tea.
(31:01) Personally, I think it tastes terrible. (31:03) Um, but pills don't taste like anything. (31:05) So I, I love green tea.
Julian Hayes II
(31:07) I'm, I'm, I like tea and I'm willing to make that switch, but I'm thinking that it's going to take a lot of green tea in a day to get what I can get it in a capsule.
Dr. Sandra Kaufmann
(31:17) So a normal cup of green tea, uh, has about 40 milligrams and a capsule has 400 milligrams. (31:24) So yeah, unless you want to drink 10 glasses, you're sort of behind the eight ball.
Julian Hayes II
(31:28) Yeah. (31:29) Nope. (31:29) Capsule it is.
Dr. Sandra Kaufmann
(31:31) Capsules. (31:31) I love capsules.
Julian Hayes II
(31:33) Yeah.
Dr. Sandra Kaufmann
(31:33) And I, I'm experimenting, I'm trying to convert all of my intake to liposomal. (31:37) So I just bought a liposomal version thinking that I can take a little bit less and have better bioavailability. (31:43) So we'll see.
(31:44) I'm trialing things.
Julian Hayes II
(31:45) Well, that's good. (31:46) And, um, so let's see, we have, uh, anything else after that?
Dr. Sandra Kaufmann
(31:50) So that's the panacea. (31:52) Um, I have found that in general people say, where do I start? (31:55) I can take five or six things.
(31:57) Um, you know, you throw too much at people, they kind of wig out. (32:00) So that is the best place to start. (32:03) Uh, as far as oral supplementation, I think it's considered other people may have other ideas.
(32:08) Um, there are basics. (32:10) However, you know, most people should be on some sort of a multivitamin. (32:13) Most people are micronutrient deficient by the time they get to be 45 or 50.
(32:17) You know, the omegas are important. (32:19) You know, there's a whole lot of variety of little things that are important. (32:22) Um, but then after that, then it's a matter of what do you want to target and how aggressive do you want to be?
(32:28) Um, I'm on 70 different things a day and that sort of wigs people out, but then there are people that are on a hundred and then they think that I'm a wuss ass. (32:34) So it just sort of depends on how aggressively people want to look at longevity.
Julian Hayes II
(32:40) I'm going to share that clip with some friends who think I take too much.
Dr. Sandra Kaufmann
(32:45) Yep. (32:45) You might be my guest. (32:46) Yeah.
(32:47) Yeah.
Julian Hayes II
(32:49) Yeah. (32:49) So, um, I guess somebody is wondering, okay, do you have a, is it just memory now or do you have a, did you have to like have a schedule or is it just root memory now?
Dr. Sandra Kaufmann
(32:58) You know, it's, it's actually, it's, it's, it's geographically located. (33:02) There's um, there's the morning stash that sits on the window sill in the kitchen. (33:07) There's the mid morning drug pile that I actually carry in my handbag because I'm, you know, I don't know where I'm going to be all the time and that's my, my real pharmaceutical pile.
(33:18) And then there's a lunch pile I create. (33:20) I have a stack, so I have little containers and I bring that to work every day. (33:24) And then there are a few more things that I take at night.
(33:26) So it's actually, it's just geographically located.
Julian Hayes II
(33:30) Okay. (33:30) Yeah. (33:31) I think that's, yeah, it's not as difficult as most people think.
Dr. Sandra Kaufmann
(33:36) It's really not. (33:36) It's not, you don't sit there and obsess about what every little thing is. (33:40) Every time you take it, you end up with a little cocktail dish of your nutrients that you take out at lunch or breakfast and you just sort of consume them and it's not really a big deal at all.
Julian Hayes II
(33:51) Yeah. (33:52) And I think it's also, you know, for me when I was first getting started, it's a, you do it a little bit and then you start to feel a certain kind of way. (33:59) You start to feel better perhaps and it's easier to stick to it because you're building momentum with it and everything's like any new habit.
Dr. Sandra Kaufmann
(34:06) Oh, without a doubt, without a doubt. (34:08) And it's, it's sort of funny when I don't do it, I feel somehow empty and then realizing people be like, Oh, you're psychologically dependent. (34:14) And I probably am.
(34:16) Um, but I will tell you that when you go on vacation, you can't really take 70 things with you all the time. (34:21) Right? (34:21) So then you have to pick and choose and it's like picking your favorite children.
(34:24) It's kind of painful. (34:26) Um, and I used to, I haven't been on a crazy adventure since COVID, but I used to go on some massively crazy adventures and you can't take 70 things. (34:34) And I can tell you that after about six or seven days of not taking a variety of things, you're really dragging.
(34:40) You can significantly feel the difference.
Julian Hayes II
(34:43) Okay. (34:44) So, um, as we get ready to kind of wrap this up here, uh, let's, let's go back. (34:48) Let's do specific a few areas.
(34:49) So when I think about the like skin aging and supplementing compounds for skin aging, um, astaxanthin, I don't know. (34:56) Um, you know, as I was researching it, it's also supposed to be like a internal sunscreen, as I say in quotations, I don't know how strong that is. (35:04) Is that strong enough to where someone probably could do without sunscreen?
Dr. Sandra Kaufmann
(35:09) Right. (35:09) So as a physician, I can never recommend that people don't use sunscreen, right? (35:12) That's kind of like the Hippocratic oath and it's whatever, whatever, whatever.
(35:16) That being said, that being said, uh, I live in Miami. (35:20) I am uber pale. (35:21) My children are uber pale.
(35:23) Um, we rarely use sunscreen. (35:25) We take a lot of Astaxanthin. (35:27) Um, it is the most, um, stolen bottle from the window sill that we have because the kids are like, Oh, I'm going out on the boat with my friends and they swiped the bottle.
(35:37) So I generally have two or three of them sitting there. (35:39) Um, I think that all of my kids' friends are actually on Astaxanthin at this point because I, you know, it's, it's Miami. (35:46) We have people of every color, creed, nationality, you know, tone of beige and even the blackest of black, they love the Astaxanthin.
(35:55) It is really, really astounding. (35:56) It protects everybody's skin. (35:59) Um, so when my kids don't take it, we look like lobsters and I think everyone sort of like just benefits from their learning process.
Julian Hayes II
(36:08) That's an awesome testimonial. (36:11) But, um, but I mean, that's, that's the power of the compound, which, um, it's unfortunate. (36:16) It's not, I don't think it's that popular still.
Dr. Sandra Kaufmann
(36:18) I just, yeah, it baffles me. (36:20) It really, although I was at an aging conference, there's a smaller one, sort of a private sort of gig, 35, 50 people. (36:27) Um, and we were asking like, who takes what?
(36:30) And by far, or is everyone put their hand up with, um, some sort of nad precursor. (36:35) Second most popular was Astaxanthin.
Julian Hayes II
(36:38) Oh, okay.
Dr. Sandra Kaufmann
(36:38) So it's, it's catching on in the longevity world. (36:41) It really is.
Julian Hayes II
(36:43) Well, good. (36:43) Cause it's, you know, um, not to beat a dead horse, but it does so many different things when you actually, if you just do a quick Google search, you'll see that this thing does so many things.
Dr. Sandra Kaufmann
(36:52) Yeah. (36:53) It's effective and there's no downside.
Julian Hayes II
(36:55) Yeah.
Dr. Sandra Kaufmann
(36:56) So I guess that's probably, if you're thinking about what else would you say with, with skin or you think, um, that's a skin is interesting because skin is sort of, I mean, the good news about skin is that you can put stuff topically and you can also put stuff systemically, right. (37:11) But at the same time, it also gets damaged systemically and topically. (37:15) So, uh, you know, it's, it's, it's both an opportunity and a problem.
(37:19) So many things are helpful for your skin. (37:21) I think collagen is very important. (37:22) I think hyaluronidase is very important. (37:24) Um, I'm a huge believer in gotu kola or it's, um, Asiatica centella, Centella asiatica rather. (37:32) Um, just amazing things are activating your fibroblasts. (37:36) Um, you know, I use TA 65 topically every other day trying to increase, uh, at least stabilize my telomerase, lengthen my skin.
(37:44) I'm constantly slathering stuff all over myself. (37:48) Um, but the good news is, you know, it had, we've got skin absorption as long as you sort of, um, use the transdermal stuff in terms of orally, your skin cells are going to be the same as the rest of yourself. (37:58) So as long as you are reasonably healthy everywhere, your, your skin cells are going to do just fine.
Julian Hayes II
(38:03) Okay. (38:04) So I'm kind of hearing that for most people, probably transdermally right.
Dr. Sandra Kaufmann
(38:10) So it's interesting. (38:11) So there's the dermal epidermal junction. (38:13) So on top is the epidermis below is the dermis, right?
(38:16) So it's like, I always talk about it's like as if it's a birthday cake in between. (38:20) There's a layer. (38:21) If you can sort of picture the frosting of a birthday cake, um, when you are young, um, it's, it's very vacillatory.
(38:28) Like if you were to peel it apart, it would look like a crate, right? (38:31) Lots of surface area. (38:32) As you get older, it sort of flattens.
(38:35) So the surface area is less. (38:37) So as you get older, topical stuff is not going to be as useful, um, as when you're younger, unfortunately, because that's when you need it. (38:46) Um, but that's the way it works.
(38:48) So the older you get, the more you need to do things sort of systemically makes sense.
Julian Hayes II
(38:54) Body's not, I guess, body's not as efficient in as it's getting older. (38:57) Yeah. (38:58) So, well, that's, you know, it's just the way it is.
Dr. Sandra Kaufmann
(39:02) Unfortunately, it is what it is that, that being said, you know, the skin is always, you know, two tiered approach, topical and systemic.
Julian Hayes II
(39:11) Yeah. (39:11) And so, um, you know, one of the last things as we, um, you had a bunch of different compounds and solutions highlighted in the second book, what are maybe two to three that stick out to you the most? (39:22) I know maybe it's like picking kids, but if you had to pick, what are, what are some of them?
Dr. Sandra Kaufmann
(39:26) Right. (39:26) So, so I guess my top three favorites of book two have to be spermidine, magnesium threonate, and fisetin.
Julian Hayes II
(39:34) Okay.
Dr. Sandra Kaufmann
(39:35) Just amazing compounds. (39:37) Truly amazing compounds.
Julian Hayes II
(39:40) So when I hear, so fisetin and quercetin, they're both in the senolytic family, right? (39:46) Um, would you, could they be interchangeable or is there something different about fisetin that makes it stand out over quercetin?
Dr. Sandra Kaufmann
(39:54) I like fisetin better than quercetin. (39:56) I think they've never had a head to head that I know about. (40:00) I like, I think that quercetin is probably slightly better at mast cell stabilization, but I think fisetin is better at other things.
Julian Hayes II
(40:06) Okay.
Dr. Sandra Kaufmann
(40:07) In terms of the senolytics, um, all the studies have been done for the most part on quercetin, fisetin will be catching up. (40:14) Um, overall, however, I think that fisetin does just so many things in so many good categories. (40:19) Um, and then in terms of the senolytic therapies, I tend to rotate them.
(40:23) So I'll do a high dose quercetin, a high dose fisetin, combine it with the, dasatinib, um, because that's what, you know, we're all used to seeing. (40:31) Um, and then I'll also go, some of the antibiotics will do it as well. (40:35) Some of the erythromycin derivatives.
(40:37) So roxethromycin is a senolytic, uh, as well as Z-packs erythromycin does it. (40:43) So there's a whole lot of different things you can sort of rotate through the senolytic departments.
Julian Hayes II
(40:48) Okay. (40:48) I probably just haven't looked into fisetin as much because quercetin, uh, with the mast cells and my my allergies, that's probably what initially got me there.
Dr. Sandra Kaufmann
(40:57) So I know a lot of men with asthma that love quercetin. (41:01) They really, really do. (41:02) It tends to be a little bit better for men than women.
Julian Hayes II
(41:05) Um, maybe that's why I like fisetin a little bit more, but that would be interesting if it panned out that way that, um, just by whatever means that men tend to gravitate toward that. (41:16) But I do know with it, with the histamines and all that, that the quercetin, um, it did pretty well for me when I was taking it consistently, which yeah, it has to be consistent, but that's yeah, that was my problem.
Dr. Sandra Kaufmann
(41:30) Yeah. (41:31) You have to take it. (41:32) Yeah.
Julian Hayes II
(41:33) So, and, um, so mag threonate, do you like that? (41:37) Um, mainly for the, is it that's more for the cognition, right? (41:40) For the brain.
Dr. Sandra Kaufmann
(41:41) Right. (41:41) Well, so 60% of people on a Western diet are magnesium deficient, right? (41:46) Be it, you know, where we've grown food or house process kind of, you know, multifactorial.
(41:52) Um, so if you're going to take magnesium anyway, right. (41:55) And you should, if you're, if you're deficient, it does a variety of things. (41:59) It stabilizes your DNA.
(42:01) Obviously it helps with muscle, helps with a variety of things. (42:04) But the only one that gets into your CNS to help with hippocampal plasticity is the magnesium three and eight. (42:10) So that's why it's my favorite.
(42:12) So as we get older and people are worried about cognitive decline, um, it's just a fantastic alternative.
Julian Hayes II
(42:20) And a lot of these, um, like some of these, like I know the magnesium three and eight, it comes in a capsule, but you can also do a powder. (42:28) It doesn't, doesn't matter, right? (42:29) This is personal preference.
Dr. Sandra Kaufmann
(42:32) Powders are disgusting. (42:33) How's that for personal preference? (42:35) I can't say powders.
(42:36) They taste terrible. (42:38) People go, Oh, I put them in my smoothie. (42:39) And then your smoothie tastes like you're drinking the bag of chalk.
(42:42) I, I'm a huge capsule fan. (42:43) So I get very disappointed if you can't get something in a capsule. (42:47) That being said, it's obviously, you know, whatever people gravitate towards.
Julian Hayes II
(42:51) Yeah. (42:51) See, I'm a weirdo. (42:52) I can, I can sometimes just hold my nose and, and if I needed to, and a powder, I can just put it in water and drink it.
(42:57) It's not good. (42:58) I'm just doing it for the cause. (43:00) And sometimes I'm just like, it's whatever.
Dr. Sandra Kaufmann
(43:02) You're a tough man. (43:04) Good for you.
Julian Hayes II
(43:07) Oh man. (43:07) So yeah. (43:08) You know, anything for the cost, right?
Dr. Sandra Kaufmann
(43:10) Good for you. (43:11) Yes. (43:11) Yes.
(43:13) It's in a capsule. (43:14) It's just so much easier.
Julian Hayes II
(43:15) It is. (43:16) And so, um, but yeah, I want to be mindful of your time and everything. (43:19) And, um, thank you.
(43:20) I know you had a little cold and everything, and we couldn't even, you couldn't even tell.
Dr. Sandra Kaufmann
(43:24) Well, um, apparently my drugs are finally working for me and I cheated. (43:28) I will tell you, uh, that I shot up with some exosomes yesterday and it has helped tremendously.
Julian Hayes II
(43:34) I haven't used those.
Dr. Sandra Kaufmann
(43:36) So exosomes are super amazing. (43:39) Um, I, I like to think about longevity in terms of the longevity pyramid, right? (43:44) There are things that you do every day.
(43:46) And then I sort of put them in the bottom ranks of my pyramid. (43:49) And then there are things you do every month or two, and then so on and so forth, you know, with less frequency. (43:53) So I use exosomes every month.
(43:58) Um, and I just feel like it makes me feel amazing. (44:01) So I did it yesterday and like my cold just, it's so much better.
Julian Hayes II
(44:07) That's awesome. (44:08) Just awesome. (44:09) So many toys, so many cool things out there.
(44:12) It's, you know, um, it's a very good time to be in this field in whatever aspect.
Dr. Sandra Kaufmann
(44:16) Oh, it's so much fun. (44:17) It's so entertaining. (44:18) Yes.
(44:19) You turn around and there's like a new therapy and it's just like Christmas. (44:21) It's so cool.
Julian Hayes II
(44:23) So, um, where can listeners keep up with you? (44:26) And, um, on your third book, are you gonna do another book?
Dr. Sandra Kaufmann
(44:29) I'm working on book three. (44:31) Absolutely. (44:33) Um, uh, I try to put whatever seminars or lectures I'm going to do on Instagram, which is a kaufmann anti-aging.
Julian Hayes II
(44:38) Okay.
Dr. Sandra Kaufmann
(44:39) Um, the internet or the website is kaufmannprotocol.com (44:44) Um, and I am actually working on with some partners to open a longevity clinic in Miami. (44:51) So we are aiming to open up, uh, February or March.
(44:54) I've sort of gotten harassed by people around the world. (44:57) Like, why can't we just come and see you? (44:58) And I'm like, well, cause I'm an anesthesiologist.
(45:00) So hopefully soon, uh, that will be an available option.
Julian Hayes II
(45:06) Awesome. (45:06) And you'll have all those, those good things in there, right?
Dr. Sandra Kaufmann
(45:09) Absolutely. (45:10) Everyone will be put on the most appropriate protocols for their age and their, their concomitant medical issues. (45:15) Absolutely.
Julian Hayes II
(45:16) Awesome to hear. (45:17) And, uh, I will have those links in the, in the bio and then also links to each of the books as well. (45:21) Uh, Dr. kaufmann, thank you so much for joining me again. (45:24) I really appreciated this. (45:25) Um, and, uh, I'm sure the listeners did as well. (45:28) They got to take, go to science class, revisit high school, and then, but didn't get also a glimpse of the future as well.
(45:35) So, you know, we got a little bit of everything in this episode. (45:37) So thank you again.
Dr. Sandra Kaufmann
(45:39) My absolute pleasure. (45:40) This is fun.
Julian Hayes II
(45:41) And everyone else stay awesome, be limitless. (45:43) And as always, go be the CEO of your health and your life. (45:46) Peace.
